The digitalization of the state is the object of close scientific discourse, especially in terms of the implementation of administrative reforms and the description of the storyline of the formation and development of new tools and forms in modern public administration.A meaningful analysis of an extensive layer of scientific publications shows tha
High Levels of ROS Impair Lysosomal Acidity and Autophagy Flux in Glucose-Deprived Fibroblasts by Activating ATM and Erk Pathways
Under glucose deprivation, cells heavily mobilize oxidative phosphorylation to maintain energy homeostasis.This leads to the generation of high levels of ATP, as well as reactive oxygen species (ROS), from mitochondria.In nutrient starvation, autophagy is activated, likely to facilitate resource recycling, but recent studies suggest that autophagy
Procedural Justice or Substantive Justice: Review of Constitutional Court Decision Number: 91/Puu/Xviii/2020
The formal test application of the Omnibus Law of Job Creation through the Constitutional Court Decision Number:91/PUU-XVIII/2020, in its statement the Constitutional Court declared its unconstitutional conditional.The Constitutional Court decision was made because considering the need to balance the formal and the strategic objectives of the estab
Protective and restorative effects of the traditional Chinese medicine Jitai tablet against methamphetamine-induced dopaminergic neurotoxicity
Abstract Background Methamphetamine (METH) is a psychostimulant with high abuse liability that affects the NEON GREEN monoamine neurotransmitter systems, particularly the dopamine system.Currently there are no effective medications for the treatment of METH abuse to restore METH-induced dopaminergic dysfunction.The Jitai tablet (JTT), a commercial